Nobivac L4 Side Effects. Nobivac l4, a novel tetravalent leptospira vaccine manufactured by merck animal health, is well tolerated and produces variable seroconversion, according to a study recently. Shown to be effective for vaccination of healthy dogs 8 weeks of age or older against canine distemper virus, canine adenovirus type 1 (hepatitis), canine parainfluenza virus,.
The most common vaccine reactions in dogs are lethargy and soreness, which may or may not be combined with a mild fever. The nobivac l4 lepto vaccine, which was rolled out in the uk. Parvovirus causes lethargy, abdominal pain, vomiting,.